# These 10 Medications May Raise Your Risk of Heat-Related Illness
Summer heat brings real risks for kids and adults taking certain medications. Ten common drug classes can impair your body's ability to cool itself or increase heat production, making heat exhaustion and heat stroke more likely during hot weather.
Anticholinergic medications top the list. These drugs, used for allergies, asthma, and bladder control, block sweating—your body's primary cooling mechanism. Antihistamines like diphenhydramine (Benadryl) and prescription options like oxybutynin fall into this category.
Stimulant medications including amphetamine-based ADHD drugs (Adderall, Vyvanse) increase metabolic rate and core body temperature. Children on these medications need extra monitoring during heat waves and athletic activity.
Antidepressants and antipsychotics affect temperature regulation through different pathways. Selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics like quetiapine (Seroquel) reduce sweating capacity.
Decongestants containing pseudoephedrine narrow blood vessels, limiting the body's ability to release heat through the skin. Topical and oral stimulants behave similarly.
Diuretics and certain blood pressure medications (beta-blockers, ACE inhibitors) interfere with fluid balance and heat dissipation. Thyroid medications can elevate metabolic heat production.
Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen reduce sweating when used repeatedly in heat.
Parents should not stop medications without consulting their pediatrician. Instead, take preventive steps: increase fluids significantly, avoid peak heat hours, wear light clothing, and watch for heat